ICE has strong instrument platform and experienced team supporting PROTAC assay development such as:
Protein purification, biophysics platform, binary and ternary biochemical assay development. HiBiT-based cell line generation and NanoBRET-based PPI assays; Fast turnaround time on classical WB optimization and then transferable to digital WB (Jess) and 384-well based In-cell western (Li-cor) and Immunofluorescence assay (Operetta); Proteomics and Cryo EM capability for novel target and molecules, troubleshooting using LC-MS/MS platform, GPCR and ion channel panel support novel PROTACs target membrane proteins~!
Welcome more detailed discussions if you have any interest on protein degradation integrate solutions.
