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上海信裕生物科技有限公司
HRPT2抗体

HRPT2抗体

商家询价

产品名称： HRPT2抗体

英文名称： HRPT2Antibody

产品编号： XY12310-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 HRPT2抗体

Applications
In-house applications ELISA, WB, IHC, IF, IP     Application not tested? Please see our Guarantee.
Species specificity Human,Mouse,Rat; other species not tested.
Images
Prev12NextView more validation data
  • 12310-1-AP;human lung tissuehuman lung tissue were subjected to SDS PAGE followed by western blot with 12310-1-AP(HRPT2; CDC73 antibody) at dilution of 1:500
  • 12310-1-AP;human breast cancerImmunohistochemical of paraffin-embedded human breast cancer using 12310-1-AP(HRPT2; CDC73 antibody) at dilution of 1:50 (under 10x lens)
  • 12310-1-AP;HelaImmunofluorescent analysis of Hela cells, using CDC73 antibody 12310-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IgG (green). Blue pseudocolor = DAPI (fluorescent DNA dye).
  • 12310-1-AP;mouse testis tissueIP Result of anti-HRPT2; CDC73 (IP:12310-1-AP, 4ug; Detection:12310-1-AP 1:500) with mouse testis tissue lysate 4000ug.
Positive WB detected in Human lung tissue, human heart tissue, mouse testis tissue
Positive IP detected in Mouse testis tissue
Positive IHC detected in Human breast cancer tissue
Positive IF detected in Hela cells
Recommended dilution WB : 1:200-1:2000
IP : 1:200-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200
 HRPT2抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information HRPT2抗体
Immunogen HRPT2 fusion protein ag2959 Full name Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Calculated molecular
weight		 531aa,61 kDa Observed molecular 
weight		 61 kDa
GenBank accession 
number		 BC014351 Gene ID (NCBI) 79577
Gene symbol CDC73 Synonyms C1orf28, CDC73, FLJ23316, HPT JT, HRPT2, Hyperparathyroidism 2 protein, Parafibromin
Background

Parafibromin is a product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2/CDC73, a putative tumor suppressor gene recently implicated in the autosomal dominant hyperparathyroidism-jaw tumor familial cancer syndrome, sporadic parathyroid cancer, and a minority of families with isolated hyperparathyroidism (PMID: 15580289). Defects in CDC73 are causes of hyperparathyroidism type 1 (HRPT1) and hyperparathyroidism type 2 (HRPT2) as well as parathyroid carcinoma (PRTC) (PMID: 12434154). Tumor suppressor parafibromin to the transcription elongation and RNA processing pathway as a PAF1 complex- and RNA polymerase II-bound protein (PMID: 15923622). Besides, parafibromin is also involved in post-transcriptional control pathways (PMID: 16116486). Recent report has revealed that pathogenic mutation, such as CDC73 gene mutation, is able to affect histone monoubiquitination (PMID: 22021426). HRPT2抗体

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